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In vivo mucoadhesive strength appraisal of gum Manilkara zapota BJPS
Sudarshan,Singh; Sunil B,Bothara.
The mucilage (MMZ) extracted from the seeds of Manilkara zapota(Linn.) P. Royen syn. using maceration techniques was evaluated for mucoadhesive strength by various in vitro and in vivo methods. The result showed that mucoadhesive strength of seeds mucilage have comparable property toward natural and synthetic polymers such as Guar Gum and hydroxyl propyl methyl cellulose (HPMC E5LV) under the experimental conditions used in this study. Briefly, it could be concluded that the seed mucilage of Manilkara zapota can be used as a pharmaceutical excipient in oral mucoadhesive drug delivery systems. Further, it may be appropriate to study the changes in these properties after chemical modifications.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Manilkara zapota/use/pharmaceutics; Manilkara zapota/evaluation/mucoadhesive strength; Drugs/mucoadhesives/oral delivery systems; Natural polymers; Pharmaceutical excipients.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300689
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Preparation and characterization of microcapsules of Pterodon pubescens Benth. by using natural polymers BJPS
Reinas,Alexandre Espada; Hoscheid,Jaqueline; Outuki,Priscila Miyuki; Cardoso,Mara Lane Carvalho.
An oleaginous fraction obtained from an alcohol extract of the fruit of Pterodon pubescensBenth. (FHPp) was microencapsulated in polymeric systems. These systems were developed using a complex coacervation method and consisted of alginate/medium-molecular-weight chitosan (F1-MC), alginate/chitosan with greater than 75% deacetylation (F2-MC), and alginate/low-molecular-weight chitosan (F3-MC). These developed systems have the potential to both mask the taste of the extract, and to protect its constituents against possible chemical degradation. The influence of the formulation parameters and process were determined by chemical profiling and measurement of the microencapsulation efficiency of the oleaginous fraction, and by assessment of microcapsule...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pterodon pubescensBenth./pharmacognosy; Sucupira; Microcapsules/preparation; Vouacapans; Alginate; Chitosan; Coacervation method; Natural polymers; Natural products.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400919
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